Synthesis of 1,2,3,4-tetrahydroacridine based 1,2,3-triazole derivatives and their biological evaluation as dual cholinesterase and α-glucosidase inhibitors
A series of new 1,2,3-triazole-linked tacrine derivatives were synthesized using click reaction of C4-functionalized 9-azido-1,2,3,4-tetrahydroacridines and various phenyl acetylenes including tacrine-based terminal alkynes.
Authors
- Thangellapally Shirisha (ORCID: https://orcid.org/0000-0002-4496-8211)
- K. Divakar (ORCID: https://orcid.org/0000-0002-7387-6228)
- Dhurke Kashinath (ORCID: https://orcid.org/0000-0002-2509-0386)
- Subir Majhi (ORCID: https://orcid.org/0009-0001-7132-8017)
Institutions
- National Institute of Technology Warangal (IN)
Publication Details
- Journal
- New Journal of Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5nj02221e
- Citations
- 1
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Ministry of Education, India
- Science and Engineering Research Board