Evaluation of the Anti-Inflammatory Potential of Solanum Species Extracts in Laboratory Animals

Context: Solanum tuberosum, Solanum torvum, Solanum nigrum are used in traditional medicine for the treatment of pain and inflammation. Aims: To evaluate the anti-inflammatory potential of Solanum species. The present research work was planned to evaluate the anti-inflammatory activity of ethanolic extract of Solanum tuberosum leaves and roots, Solanum torvum leaves and roots, Solanum nigrum leaves and roots. Settings and Design: Extraction is done by Soxhlet method. Ethanolic extract was evaluated at dosage of 500mg/kg per os (by mouth) in rats. Six rats in each group were used for this study, Test samples were given orally as per standard protocol and animals were observed for signs and symptoms along with weekly Body weight. The present study is divided into two parts Part one study was to evaluate the Anti-inflammatory activity of Solanum Species in Wistar rats by carrageenan induced paw edema model and part two study was to evaluate the Anti-inflammatory activity of Solanum Species in Wistar rats by Histamine induced paw edema model. Statistical Analysis: pharmacological screening models- Carrageenan induced rat paw edema and Histamine induced rat paw edema. Data obtained was analysed using unpaired T- test and one way anova, where P ≤ 0.05 is considered as statistically significant. Results: Given treatment (500 mg/kg) did not show anti-inflammatory activity in Solanum tuberosum and Solanum torvum against carrageenan and histamine induced rat paw edema but Solanum nigrum showed anti-inflammatory activity against carrageenan and histamine induced rat paw edema. Conclusion: Present study results supported the traditional use of plant Solanum nigrum in traditional medicine for their anti-inflammatory activity.