Single Cell Profiling in the Sox10 Hirschsprung Mouse Implicates Hox Genes in Enteric Neuron Trajectory Allocation
Sox10<sup>Dom/+</sup> mutation shifts enteric neuron types by altering neuronal trajectories early in ENS development. Multiple neurogenic transcription factors are reduced in Sox10<sup>Dom/+</sup> scRNA-seq profiles. This work is the first to correlate changes in Hox expression, notably Hoxa6, with alterations in enteric neuron trajectories.
Authors
- E. Michelle Southard‐Smith (ORCID: https://orcid.org/0000-0003-4718-5869)
- Justin A. Avila (ORCID: https://orcid.org/0000-0002-8780-7610)
- David K. Flaherty
- Joseph T. Benthal (ORCID: https://orcid.org/0000-0002-7078-837X)
- Jenny C. Schafer (ORCID: https://orcid.org/0000-0003-2505-5457)
Institutions
- Vanderbilt University (US)
- Vanderbilt Health (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101590
- Citations
- 4
- Primary Topic
- Congenital gastrointestinal and neural anomalies
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- Howard Hughes Medical Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Child Health and Human Development