What are the clinical (endoscopic) differentials of celiac disease in dyspeptic syndrome?

ABSTRACT Background: Dyspepsia is a set of symptoms of the upper abdomen and has a prevalence of 10–45% of the population with different etiological possibilities, including celiac disease. Aim: The aim of this study was to evaluate the prevalence of celiac disease in patients with a clinical diagnosis of dyspeptic syndrome. Methods: This is an observational research, based on a review of medical records of patients treated for uninvestigated dyspepsia. Patients over 18 years of age, with uninvestigated dyspepsia, and who had upper endoscopy, total immunoglobulin A (IgA), and antitissue transglutaminase IgA were included. Those with diarrhea, constipation, malabsorption, refractory lactose intolerance, or who presented extraintestinal signs or symptoms suggestive of celiac disease were excluded. Results: The initial sample was 1,802 records and the final 200 patients. Considering the total sample, the average age was 45.13 years and the female sex was predominant. Symptoms associated with gluten were reported in 6% of the patients. The antitissue transglutaminase IgA was positive in 1.5% of the patients. Considering the sample of 100 patients, the diagnosis of celiac disease had a prevalence of 3%. Conclusions: The prevalence of celiac disease in patients with a clinical diagnosis of dyspeptic syndrome was 3%.