Simultaneous resection of colorectal cancer and liver metastases
ABSTRACT Although the presence of synchronous colorectal liver metastases (CRLM) represents an important prognostic factor for recurrence-free survival (RFS) and overall survival (OS), the definitions of synchronicity are variable in the literature, including metastases at the time of diagnosis, or even before the diagnostic of the primary site of colorectal cancer (CRC), until either six or 12 months after the time of diagnosis, according to the author of each study. Simultaneous approaches to treat CRC and CRLM seem to be safe for patients carefully selected without jeopardizing oncologic outcomes, with similar complication rates, shorter hospital length of stay, and operation times even for major hepatectomies. However, there is no consensus about the optimal timing to approach the primary tumor and CRLM, whether simultaneously or staged, and both performance status and the presence of symptoms play important roles in the treatment sequence, perhaps avoiding two high-risk procedures at the same time.
Authors
- Aleksandar Karamarković (ORCID: https://orcid.org/0000-0001-5716-2009)
- Marcelo Moura Linhares (ORCID: https://orcid.org/0000-0002-9540-5937)
- Raphael L. C. Araújo (ORCID: https://orcid.org/0000-0002-7834-5944)
- Olivier Soubrane (ORCID: https://orcid.org/0000-0002-2059-1237)
- Timothy Michael Pawlik (ORCID: https://orcid.org/0000-0002-7994-9870)
- Paulo Herman (ORCID: https://orcid.org/0000-0003-2859-5846)
- Maria Ignez Braghiroli (ORCID: https://orcid.org/0000-0001-6366-8786)
- Ricardo Lemos Cotta-Pereira (ORCID: https://orcid.org/0009-0006-0755-0883)
- Hugo P. Marques (ORCID: https://orcid.org/0000-0003-3540-0488)
- A.R. Teixeira (ORCID: https://orcid.org/0000-0001-6086-2460)
- René A. Adam (ORCID: https://orcid.org/0000-0003-2169-5449)
Institutions
- Délégation Paris 5 (FR)
- Universidade de São Paulo (BR)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- University of Belgrade (RS)
- Unidade Local de Saúde de São José (PT)
- D’Or Institute for Research and Education (BR)
- Fundação Instituto de Pesca do Estado do Rio de Janeiro (BR)
- The Ohio State University (US)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1590/0102-67202025000014e1883
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00