Differential Protective Roles of c-Jun N-terminal Kinase-2 in Nonparenchymal Liver Cells and Hepatocytes During Cholestasis
Besides in hepatocytes, JNK2 in NPCs-but not in BM-derived cells-confers protection during cholestasis. After BDL, a JNK2-dependent mechanism directs the inflammatory response involved in regulating biliary transporters. Hence, our data define JNK2 as a critical target during cholestasis in NPCs.
Authors
- Christian Trautwein (ORCID: https://orcid.org/0000-0003-2762-8247)
- Francisco Javier Cubero
- Pavel Strnad (ORCID: https://orcid.org/0000-0002-7122-6379)
- Roger J. Davis (ORCID: https://orcid.org/0000-0002-0130-1652)
- Kai Markus Schneider (ORCID: https://orcid.org/0000-0002-0047-3794)
- Chi Xu (ORCID: https://orcid.org/0000-0001-5470-7376)
- Carolin Victoria Schneider (ORCID: https://orcid.org/0000-0002-6728-9246)
- Jan Georg Hengstler (ORCID: https://orcid.org/0000-0002-1427-5246)
- Antonio Molinaro (ORCID: https://orcid.org/0000-0002-3456-7369)
- Ines Volkert (ORCID: https://orcid.org/0009-0005-6094-8375)
- Mohamed Ramadan Mohamed (ORCID: https://orcid.org/0000-0002-2101-2030)
- Gang Zhao (ORCID: https://orcid.org/0000-0002-3904-0216)
Institutions
- Universidad Complutense de Madrid (ES)
- Howard Hughes Medical Institute (US)
- University of Massachusetts Chan Medical School (US)
- TU Dortmund University (DE)
- Shanghai East Hospital (CN)
- Leibniz Research Centre for Working Environment and Human Factors (DE)
- University of Gothenburg (SE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101588
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Wageningen University and Research
- European Regional Development Fund