Periodontitis-induced neuroinflammation triggers IFITM3-Aβ axis to cause alzheimer’s disease-like pathology and cognitive decline
We define a previously unidentified link between periodontitis and cognitive decline, and provide new evidence linking oral pathogenic bacteria-induced innate immunity and neuroinflammation to AD pathogenesis and cognitive decline, partly through increased blood-brain barrier (BBB) permeability, triggered neuroinflammation, and elevated IFITM3 in glial cells for Aβ deposition. Moreover, periodontitis exacerbates innate immunity and cognitive impairment in AD mice, underscoring the importance of preventive and therapeutic strategies for periodontal disease in AD patients.
Authors
- Xumeng Wang (ORCID: https://orcid.org/0000-0002-9525-9298)
- Yonggang Zhao
- Fu Wang (ORCID: https://orcid.org/0000-0001-9615-1038)
- Songlin Wang (ORCID: https://orcid.org/0000-0002-7435-2637)
- Juanjuan Li (ORCID: https://orcid.org/0000-0002-0074-1453)
- Lu Gao (ORCID: https://orcid.org/0000-0002-9264-6655)
- Weixian Chen (ORCID: https://orcid.org/0000-0001-6973-9338)
- Lingwenyao Kong
Institutions
- Capital Medical University (CN)
- Dalian Medical University (CN)
- Jinan Stomatological Hospital (CN)
- State Key Laboratory of New Ceramics and Fine Processing
- Tsinghua University (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1186/s13195-025-01818-3
- Citations
- 8
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 6.38
Funders
- National Natural Science Foundation of China