Slow virologic control but strong immune and metabolic recovery with dolutegravir-anchored therapy in an HIV cohort in Ghana
This study highlights the significant reduction in viral load and improved immune recovery following ART initiation despite uncontrolled viremia in a subset of participants. This cohort presents an opportunity to study Ghana's local HIV epidemic, including HIV-1 and HIV-2, and impact of ART on disease progression.
Authors
- Becky Tetteh (ORCID: https://orcid.org/0009-0003-7014-8983)
- Christèle Nguepou Tchopba
- Peter K. Quashie (ORCID: https://orcid.org/0000-0003-4114-5460)
- Evelyn Yayra Bonney (ORCID: https://orcid.org/0000-0002-6634-8742)
- Mark Appeaning (ORCID: https://orcid.org/0000-0001-5633-4024)
- Edwin O. Magomere (ORCID: https://orcid.org/0000-0002-7735-1576)
- Gloria Akosua Ansa (ORCID: https://orcid.org/0000-0002-5538-7578)
- Bridget Quist
- Alberta Mawulawoe Abotsi
- Nana Ama Yeboaa Amoako
- Kirk Elorm Kouffie
Institutions
- University of Ghana (GH)
- The Francis Crick Institute (GB)
- Noguchi Memorial Institute for Medical Research (GH)
- Koforidua Technical University (GH)
- Ghana Health Service (GH)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1186/s12985-025-02873-w
- Citations
- 2
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Bill and Melinda Gates Foundation
- Wellcome Trust
- Francis Crick Institute
- Cancer Research UK
- Ghana National Petroleum Corporation
- Medical Research Council