Asymmetric Synthesis of Chiral Diamines via a Low-Loading Ir-Catalyzed Umpolung Allylation of Imines
A general and mild method for the synthesis of homoallylic 1,2-diamines from α-amino aldimines is reported. This method capitalizes on a low-loading iridium-catalyzed asymmetric umpolung allylation of imines and the following facile 2-aza-Cope rearrangement. The reagents are derived from readily available starting materials, and the catalytic system enables efficient construction of chiral vicinal diamines under mild conditions with broad functional group tolerance.
Authors
- Dawen Niu (ORCID: https://orcid.org/0000-0002-5114-4413)
- Rong Shi (ORCID: https://orcid.org/0000-0002-5152-3026)
- Hongbao Sun (ORCID: https://orcid.org/0000-0002-7956-0232)
- Yingwei Wang (ORCID: https://orcid.org/0000-0002-9118-5164)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1021/acs.orglett.5c02466
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nuclear Power Institute of China
- National Natural Science Foundation of China
- Sichuan University
- Sichuan Province Science and Technology Support Program