Mediating factors between autoimmune thyroiditis and breast cancer: a bidirectional Mendelian randomization study
AIT can increase the risk of breast cancer, there is no causal link in the reverse direction. Among the 1400 metabolites, 7-methylxanthine is a mediator of AIT to breast cancer. There were no mediators from AIT to breast cancer in the 211 gut microbiome taxa.
Authors
- Huazhi Li
- Lei Wang (ORCID: https://orcid.org/0000-0001-7103-9402)
- Xin Pei (ORCID: https://orcid.org/0009-0003-9949-9453)
- Xianyang Chen (ORCID: https://orcid.org/0000-0003-0405-9029)
- Nan Jiang (ORCID: https://orcid.org/0000-0002-4015-5360)
Institutions
- Beijing Institute of Big Data Research (CN)
- Beijing Chest Hospital (CN)
- Institute of Genetics and Developmental Biology (CN)
- Beijing Chuiyangliu Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1007/s12672-025-03206-7
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00