Targeting Hepatic Stellate Cell PD-L1 Alters Liver Inflammation and Fibrosis in CCl4 Liver Injury Mouse Model
Targeting HSC PD-L1 altered HSC transcriptome and liver inflammation, and suppressed liver fibrosis, representing a potential therapeutic strategy for liver fibrosis.
Authors
- Ningling Kang (ORCID: https://orcid.org/0000-0002-4565-7976)
- Tatiana Kisseleva (ORCID: https://orcid.org/0000-0001-9107-2306)
- Aurpita Shaha (ORCID: https://orcid.org/0000-0001-5681-903X)
- Lianping He (ORCID: https://orcid.org/0000-0002-9627-5599)
- Vijay H. Shah (ORCID: https://orcid.org/0000-0001-7620-573X)
- Sofía Jerez (ORCID: https://orcid.org/0000-0002-8139-7948)
- Liankang Sun (ORCID: https://orcid.org/0000-0002-4980-8460)
- Xianghu Wang (ORCID: https://orcid.org/0000-0001-5515-0514)
- Bing Bai (ORCID: https://orcid.org/0000-0002-4082-1562)
- Yuanguo Wang (ORCID: https://orcid.org/0000-0003-4752-9908)
- Wenming Bao
Institutions
- Fox Chase Cancer Center (US)
- Mayo Clinic (US)
- Hormel (United States) (US)
- University of California San Diego (US)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Mayo Clinic in Florida (US)
- Taizhou University (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101587
- Citations
- 6
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 7.93
Funders
- National Institutes of Health
- Division of Cancer Epidemiology and Genetics, National Cancer Institute