Porcine Pilon Fractures Result in Significant Chondrocyte Cell Death on Both Sides of the Tibiotalar Joint

The rate of posttraumatic osteoarthritis after tibial plafond injuries in humans is exceedingly high despite advances in operative treatment. This study uses a clinically relevant, large-animal pilon fracture model to evaluate rates of chondrocyte cell death after 48 hours. This study confirms that cartilage cell death is associated with proximity to the fracture lines, higher-energy injury, and that pilon injuries impact cartilage on both the tibia and talus.