Common inflammatory proteins linking frailty and area-level deprivation as key drivers of cardiovascular risk in women
Our findings indicate that inflammatory proteins involved in cellular signalling, growth, and migration are associated with frailty, socioeconomic deprivation, and CVD risk, suggesting that these pathways mediate the impact of socioeconomic deprivation and ageing on CVD risk.
Authors
- Panayiotis Louca (ORCID: https://orcid.org/0000-0001-5956-1433)
- Mario Falchi (ORCID: https://orcid.org/0000-0002-5646-1004)
- Claire J. Steves (ORCID: https://orcid.org/0000-0002-4910-0489)
- Ruth C. E. Bowyer (ORCID: https://orcid.org/0000-0002-6941-8160)
- Ana M. Valdes (ORCID: https://orcid.org/0000-0003-1141-4471)
- Niccolò Rossi (ORCID: https://orcid.org/0000-0002-8285-7627)
- Frances M. K. Williams (ORCID: https://orcid.org/0000-0002-2998-2744)
- Mary Ní Lochlainn (ORCID: https://orcid.org/0000-0001-5702-1759)
- Afroditi Kouraki (ORCID: https://orcid.org/0000-0002-5976-9047)
- Cristina Menni (ORCID: https://orcid.org/0000-0001-9790-0571)
- Vasileios Georgopoulos (ORCID: https://orcid.org/0000-0002-7195-4018)
- Yu Lin (ORCID: https://orcid.org/0000-0002-5583-4374)
- Anthony J Kelly
Institutions
- University of Nottingham (GB)
- King's College London (GB)
- University of Milan (IT)
- Nottingham City Hospital (GB)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Nottingham Biomedical Research Centre (GB)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1038/s43856-025-01012-4
- Citations
- 2
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 2.45
Funders
- Wellcome Trust
- UK Research and Innovation
- Dipartimenti di Eccellenza
- National Institute for Health and Care Research
- British Heart Foundation
- King's College London
- European Commission
- Ministero della Salute
- Medical Research Council
- NIHR Nottingham Biomedical Research Centre