Pre-transplant predictors of 3-Month survival following liver transplantation for acute liver failure in adult and pediatric patients in Türkiye

This multicenter retrospective study analyzed 336 patients (236 adults, 100 children) who underwent liver transplantation (LT) for acute liver failure (ALF) between 2002 and 2019 across 14 centers in Türkiye. The aim was to evaluate pretransplant factors influencing short-term posttransplant survival. Median MELD and PELD scores were 31 and 30, respectively. The most common ALF etiologies were viral, indeterminate, and drug-induced causes. Living donor liver transplantation (LDLT) was more common in children (86.0%) than adults (57.2%). Mean posttransplant survival was 166±9 months in children and 117±6 months in adults. In adults, LDLT significantly improved survival compared to deceased donor LT (DDLT), with survival of 135 vs. 89 months (p=0.0012). Although pediatric LDLT recipients had longer mean survival than DDLT recipients (167 vs. 132 months), this difference was not statistically significant (p=0.5959). Three-month mortality was associated with low albumin and grade 4 hepatic encephalopathy (HE) in children. In adults, independent predictors of early mortality included DDLT, serum sodium >140 mEq/L, MELD >35, pH <7.3, and grade 4 HE. Our data suggest that LDLT may offer a survival advantage, particularly in adults with ALF. Identifying pretransplant risk factors is essential for improving early outcomes and guiding clinical decision-making.

Authors

Institutions

Publication Details

Journal
Scientific Reports
Published
2025-07-19
DOI
https://doi.org/10.1038/s41598-025-11298-y
Citations
2
Primary Topic
Liver Disease and Transplantation
Type
article
Field-Weighted Citation Impact
2.64
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Pre-transplant predictors of 3-Month survival following liver transplantation for acute liver failure in adult and pediatric patients in Türkiye

Meral Akdoğan, İlker Turan, Tarkan Ünek, Ender Dulundu et al.
2 citations
Scientific Reports
Liver Disease and Transplantation
2.64
article

Pre-transplant predictors of 3-Month survival following liver transplantation for acute liver failure in adult and pediatric patients in Türkiye

Meral Akdoğan, İlker Turan, Tarkan Ünek, Ender Dulundu, Genco Gençdal, Haydar Adanır, Murat Dayangaç, Figen Özçay, Ahmet Gürakar, Dinc Dinçer, Murat Akyıldız, Hale Gökcan, Ramazan Idılman, Mesut Akarsu, Fulya Günşar, Çiğdem Arıkan, Murat Aladağ, Deniz Balcı, Sezai Yılmaz, Murat M. M. Harputluoglu, Gökhan Kabaçam, Murat Zeytunlu, Yasemin Balaban, Ulus Salih Akarca, Zeki Karasu, Kâmil Yalçın Polat, Feyza Dilber, Erdal Birol Bostancı, Ahmet Doğrul, Murat Taner Gülşen, Aysun Çalışkan Kartal, Hakan Dursun
article en
2 citations

Abstract

This multicenter retrospective study analyzed 336 patients (236 adults, 100 children) who underwent liver transplantation (LT) for acute liver failure (ALF) between 2002 and 2019 across 14 centers in Türkiye. The aim was to evaluate pretransplant factors influencing short-term posttransplant survival. Median MELD and PELD scores were 31 and 30, respectively. The most common ALF etiologies were viral, indeterminate, and drug-induced causes. Living donor liver transplantation (LDLT) was more common in children (86.0%) than adults (57.2%). Mean posttransplant survival was 166±9 months in children and 117±6 months in adults. In adults, LDLT significantly improved survival compared to deceased donor LT (DDLT), with survival of 135 vs. 89 months (p=0.0012). Although pediatric LDLT recipients had longer mean survival than DDLT recipients (167 vs. 132 months), this difference was not statistically significant (p=0.5959). Three-month mortality was associated with low albumin and grade 4 hepatic encephalopathy (HE) in children. In adults, independent predictors of early mortality included DDLT, serum sodium >140 mEq/L, MELD >35, pH <7.3, and grade 4 HE. Our data suggest that LDLT may offer a survival advantage, particularly in adults with ALF. Identifying pretransplant risk factors is essential for improving early outcomes and guiding clinical decision-making.

Scientific ReportsVol. 15(1)
Bahçeşehir University (TR), Koç University (TR), Johns Hopkins University (US), Ankara University (TR), University of Health Science (KH), Başkent University (TR), Dokuz Eylül University (TR), Akdeniz University (TR), Inonu University (TR), Johns Hopkins Medicine (US), Kütahya Dumlupınar Üniversitesi (TR), Istanbul Medipol University (TR), Ege University (TR), Memorial Ankara Hospital (TR), Memorial Sisli Hospital (TR), Istanbul University-Cerrahpaşa (TR), Güven Hospital (TR), Sağlık Bilimleri Üniversitesi (TR), Istanbul Memorial Hospital (TR), Gaziantep University (TR), Atatürk University (TR), Hacettepe University (TR), Marmara University (TR)
Good health and well-being
Openalex Percentile: Top 9%
Liver Disease and Transplantation
2.64
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.