Unveiling the power of plumbagin: revitalizing exhausted T cells to combat tongue cancer
Plumbagin restores exhausted T cells'viability via multiple PD-L1/PD-1 axis, inhibiting TSCC immune escape and providing a theoretical foundation for immune microenvironment regulation.
Authors
- Runying Guo
- Rongrong Zhang (ORCID: https://orcid.org/0000-0002-2311-4348)
- Qingkun Jiang (ORCID: https://orcid.org/0000-0003-3708-6445)
- Jiaxuan Qiu (ORCID: https://orcid.org/0000-0002-4496-6056)
- Ke Guo
Institutions
- Jiujiang University (CN)
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1186/s12935-025-03892-x
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Nanchang University