TAF15 mediates ROP16-induced apoptosis and cell cycle arrest in lung cancer

Our study demonstrates that type I/III ROP16 induce apoptosis and cell cycle arrest in A549 cells through interactions with the host RNA-binding protein TAF15. These findings not only provide compelling evidence for the oncosuppressive potential of Toxoplasma gondii-derived secretory proteins but also uncover a previously unrecognized mechanism by which parasite effectors hijack host transcriptional regulators to subvert cancer cell survival pathways.