Clinical features of medication‐related osteonecrosis of the jaw in prostate cancer management
This study demonstrates that long-term denosumab treatment in patients with prostate cancer and bone metastases is associated with a substantial cumulative incidence of MRONJ. Key risk factors were identified, along with a modifiable factor that may reduce risk. These findings suggest that adjusting denosumab dosing schedules could help mitigate MRONJ risk, underscoring the need for personalised treatment plans and early preventive strategies.
Authors
- Keiichiro Miyajima (ORCID: https://orcid.org/0000-0002-7799-669X)
- Kagenori Ito (ORCID: https://orcid.org/0000-0002-4970-1727)
- Masaki Hashimoto (ORCID: https://orcid.org/0000-0002-0396-8223)
- Fumihiko Urabe (ORCID: https://orcid.org/0000-0002-2599-8183)
- Kensuke Fujiwara (ORCID: https://orcid.org/0000-0001-8284-7982)
- Kosuke Iwatani (ORCID: https://orcid.org/0000-0001-5428-852X)
- Wataru Fukuokaya (ORCID: https://orcid.org/0000-0003-1044-912X)
- Jun Miki (ORCID: https://orcid.org/0000-0002-4638-8640)
- Yuhei Koike (ORCID: https://orcid.org/0000-0003-0254-686X)
- Masaya Murakami (ORCID: https://orcid.org/0000-0002-1268-6615)
- Takafumi Yanagisawa (ORCID: https://orcid.org/0000-0002-7410-0712)
- Kojiro Tashiro
- Masanobu Nakata
- Yu Imai (ORCID: https://orcid.org/0000-0003-0971-4205)
- Yuzo Inaba
- Yuya Iwamoto (ORCID: https://orcid.org/0009-0009-1396-3192)
- Katsuhito Watanabe
- Juria Nakano
- Yuma Goto
- Yukio Ogihara
- Takahiro Kimura
Institutions
- Jikei University School of Medicine (JP)
- Katsushika Medical Center (JP)
- Kanagawa Rehabilitation Hospital (JP)
- The Jikei University Hospital (JP)
- Nagano Municipal Hospital (JP)
- Fujieda Municipal General Hospital (JP)
- Jikei University Kashiwa hospital (JP)
- JR Tokyo General Hospital (JP)
- Tsurugi Hospital (JP)
Publication Details
- Journal
- British Journal of Urology
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1111/bju.16860
- Citations
- 3
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.14