Discovery of pyroptosis-inducing natural products in neuroblastomas: computational studies with experimental validation
Our study successfully identified curcumin as a strong regulator of both apoptosis and pyroptosis, quercetin as a strong modulator of apoptosis, and galangin as a strong modulator of pyroptosis. Further research on these compounds is crucial for the development of novel therapeutic strategies for neuroblastoma treatment.
Authors
- Dyaningtyas Dewi Pamungkas Putri (ORCID: https://orcid.org/0000-0002-1235-4346)
- Yoshitaka Hippo (ORCID: https://orcid.org/0000-0002-4975-1812)
- Rohmad Yudi Utomo (ORCID: https://orcid.org/0000-0003-4803-9417)
- Yusuke Suenaga (ORCID: https://orcid.org/0000-0001-6902-5386)
- Edy Meiyanto (ORCID: https://orcid.org/0000-0002-0886-6322)
- Beni Lestari (ORCID: https://orcid.org/0000-0002-5658-0572)
- Ummi Maryam Zulfin (ORCID: https://orcid.org/0000-0002-4133-0669)
- Faaza Aulia Rahman (ORCID: https://orcid.org/0009-0000-8476-5120)
Institutions
- Universitas Gadjah Mada (ID)
- Chiba Cancer Center (JP)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1186/s12906-025-05004-8
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Universitas Gadjah Mada