Identification of chemosensory protein inhibitors as a potential strategy to combat pyrethroid resistance in <i>Anopheles gambiae</i>
Our findings suggest that high-affinity CSP inhibitors capable of competitively blocking insecticide sequestration represent a promising strategy for overcoming CSP-mediated resistance. This study provides a foundation for the development of novel insecticide synergists to enhance the efficacy of pyrethroids and combat resistance in malaria vectors. © 2025 Society of Chemical Industry.
Authors
- Mingzhi Dong (ORCID: https://orcid.org/0000-0002-8897-5931)
- Rajamanikandan Sundarraj (ORCID: https://orcid.org/0000-0002-5140-3382)
- Zhiguang Yuchi (ORCID: https://orcid.org/0000-0003-2595-9106)
- Chen Liu (ORCID: https://orcid.org/0000-0003-1635-3479)
- Ning Yang (ORCID: https://orcid.org/0000-0002-2737-4147)
Institutions
- Agricultural Genomics Institute at Shenzhen (CN)
- Tianjin Institute of Pharmaceutical Research (China) (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1002/ps.70061
- Citations
- 1
- Primary Topic
- Insect Pest Control Strategies
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City
- National Key Research and Development Program of China