Transfusion strategies in thalassemia and sickle cell disease SITE-SIMTI-SIdEM Good Practice.

This document is the tool through which the knowledge developed by biomedical research is transferred to daily clinical practice. It does not offer standards of care to which one can refer in acritical and decontextualized manner: these standards must be able to be expressed, for each individual case, on the basis of available clinical information, preferences of the patients and other contextual situations, accurately examined in light of the expertise of healthcare professionals. It is therefore up to the expertise and judgement of the professionals, who carefully listen to particular requests and consider the values expressed by patients, to establish which procedures or treatments are more appropriate to manage individual clinical cases.The Good Practice (GP) is organized in two large sections: a main section which, for each topic of interest, reports a short specific introduction and continues with recommendations for clinical practice in order to allow the reader to access the interpretation of the evidence and the recommendations made by the Authors. No. 4 Enclosures where the following is reported: Enclosure 1 - transfusion yield; Enclosure 2 - perioperative management and prevention of postoperative complications; Enclosure 3 - donation of blood, hematopoietic stem cells (HSCs), organs and tissues; Enclosure 4 - table of matching levels.