Compliance with antimicrobial stewardship guidelines in surgery: an observational, multidisciplinary, cohort study

Antimicrobial stewardship aims to improve clinical outcomes while reducing the unintended effects of antimicrobial use. The use of antibiotics in surgical wards, except for surgical antibiotic prophylaxis, has been poorly documented. Our goal was to assess the rate of compliance with the guidelines of antibiotic prescriptions in surgical wards. In a single academic center, a retrospective analysis was conducted over a two-month period to assess the rate of compliance with four criteria reflecting good practice in terms of antimicrobial stewardship: (1) decision of treatment initiation in line with the guidelines, (2) adequate spectrum of antibiotics in terms of patient characteristics; (3) duration of antibiotic treatment in compliance with the guidelines, and (4) whether re-adaptation of treatment was required. Positive responses to these four criteria indicated a 100% compliance rate. A pair of experts assessed the clinical vignettes to decide the compliance of each criterion. The secondary aims were to assess whether a 100% compliance rate was associated with positive outcomes. Among the 1,339 single stays in surgical wards, 232 patients (17%) received antibiotics during the study period. The rate of compliance with all four criteria was 33%. In addition, 149 (64%) patients complied with indication and spectrum, and 91 (39%) patients complied with indication, spectrum, and duration. Compliance with the antimicrobial treatment was associated with improved outcomes. Of the patients hospitalized in the surgical wards, antimicrobial stewardship guidelines were complied with in 33% patients. Full compliance with the guidelines was associated with improved outcomes.

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Publication Details

Journal
World Journal of Emergency Surgery
Published
2025-07-19
DOI
https://doi.org/10.1186/s13017-025-00636-0
Citations
2
Primary Topic
Antibiotic Use and Resistance
Type
article
Field-Weighted Citation Impact
2.52
Controls
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article

Compliance with antimicrobial stewardship guidelines in surgery: an observational, multidisciplinary, cohort study

Djamel Mokart, R. Gauzit, Neyla Mohammedi, Pièrre-Hugues Roche et al.
2 citations
World Journal of Emergency Surgery
Antibiotic Use and Resistance
2.52
article

Compliance with antimicrobial stewardship guidelines in surgery: an observational, multidisciplinary, cohort study

Djamel Mokart, R. Gauzit, Neyla Mohammedi, Pièrre-Hugues Roche, Marc Garnier, Mathilde Pugès, Sandro Cadaval Gonçalves, Xavier Flécher, Laurent Muller, François Dépret, Xavier Benoît D’Journo, Gabriel Birgand, Bruno Pastène, Philippe Amabile, Marc Léone, Alexandre Bleibtreu, Marwan Bouras, V. Mondain, Carole Eldin, Cyrille Bastide, François Antonini, Pierre Fillâtre, Stéphane Berdah
article en
2 citations

Abstract

Antimicrobial stewardship aims to improve clinical outcomes while reducing the unintended effects of antimicrobial use. The use of antibiotics in surgical wards, except for surgical antibiotic prophylaxis, has been poorly documented. Our goal was to assess the rate of compliance with the guidelines of antibiotic prescriptions in surgical wards. In a single academic center, a retrospective analysis was conducted over a two-month period to assess the rate of compliance with four criteria reflecting good practice in terms of antimicrobial stewardship: (1) decision of treatment initiation in line with the guidelines, (2) adequate spectrum of antibiotics in terms of patient characteristics; (3) duration of antibiotic treatment in compliance with the guidelines, and (4) whether re-adaptation of treatment was required. Positive responses to these four criteria indicated a 100% compliance rate. A pair of experts assessed the clinical vignettes to decide the compliance of each criterion. The secondary aims were to assess whether a 100% compliance rate was associated with positive outcomes. Among the 1,339 single stays in surgical wards, 232 patients (17%) received antibiotics during the study period. The rate of compliance with all four criteria was 33%. In addition, 149 (64%) patients complied with indication and spectrum, and 91 (39%) patients complied with indication, spectrum, and duration. Compliance with the antimicrobial treatment was associated with improved outcomes. Of the patients hospitalized in the surgical wards, antimicrobial stewardship guidelines were complied with in 33% patients. Full compliance with the guidelines was associated with improved outcomes.

World Journal of Emergency SurgeryVol. 20(1)
Inserm (FR), Aix-Marseille Université (FR), Centre Hospitalier Universitaire de Bordeaux (FR), Centre Hospitalier Universitaire de Nice (FR), Centre Hospitalier Universitaire de Nantes (FR), Sorbonne Université (FR), Assistance Publique Hôpitaux de Marseille (FR), Sorbonne Paris Cité (FR), Assistance Publique – Hôpitaux de Paris (FR), Centre Hospitalier de Saint-Brieuc (FR), Hôpital Nord (FR), CIC Rennes (FR), Hôpital l'Archet (FR), Hôpital Lariboisière (FR), Pitié-Salpêtrière Hospital (FR), Centre d'Investigation Clinique de Nantes (FR), Centre Hospitalier Universitaire de Clermont-Ferrand (FR), Institut des Sciences du Mouvement Etienne-Jules Marey (FR), Institut Paoli-Calmettes (FR), Hôpital de la Timone (FR), Institut de Recherche pour le Développement (FR), Yves Rocher (France) (FR), Université de Nîmes (FR), Nantes Université (FR)
Openalex Percentile: Top 9%
Antibiotic Use and Resistance
2.52
DOIOpen Access PDFOpenAlex
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