Targeting autophagy and plasminogen activator inhibitor-1 increases survival and remodels the tumor microenvironment in glioblastoma
Our findings suggest that PAI-1 may be a compensatory survival mechanism in GBM after autophagy inhibition, and that dual targeting of autophagy and PAI-1 disrupts tumor progression and enhances anti-tumor immunity, providing promising evidence for targeting this axis.
Authors
- Lianne Jaén Infante
- Christian J. Kastrup (ORCID: https://orcid.org/0000-0003-3644-0019)
- Francesca Ferraresso
- Stella E. Tsirka (ORCID: https://orcid.org/0000-0003-0022-1770)
- Sophie Shifman (ORCID: https://orcid.org/0000-0002-5794-1691)
- Daniel A. Lawrence (ORCID: https://orcid.org/0000-0003-3126-1935)
- James T. O’Connor (ORCID: https://orcid.org/0000-0002-2011-8378)
- Daniel P. Radin (ORCID: https://orcid.org/0000-0003-3775-7712)
- Aryan Sharma
Institutions
- University of British Columbia (CA)
- Medical College of Wisconsin (US)
- University of Michigan (US)
- Stony Brook School (US)
- Versiti Blood Center of Wisconsin (US)
- Stony Brook University (US)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1186/s13046-025-03473-w
- Citations
- 3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Stony Brook University
- National Institutes of Health