Does PARP1 up-regulation correlate with PSMA expression in patients with metastatic castration-resistant prostate cancer studied with [18F]PARPi and [68Ga]PSMA PET/CT?
Results showed a considerable uptake of [<sup>18</sup>F]PARPi in mCRPC patients and indicated a correlation between PARPi uptake and PSMA expression, suggesting the potential of using [<sup>18</sup>F]PARPi as a diagnostic imaging tool in mCRPC patients. More studies are needed to evaluate the clinical benefit of this innovative radiotracer.
Authors
- Sazan Rasul (ORCID: https://orcid.org/0000-0003-2898-3232)
- Pascal Baltzer (ORCID: https://orcid.org/0000-0002-3755-5398)
- Clemens P. Spielvogel (ORCID: https://orcid.org/0000-0002-4409-8324)
- Karsten Bamminger (ORCID: https://orcid.org/0000-0003-3811-7485)
- Marius Ozenil (ORCID: https://orcid.org/0000-0001-6369-6613)
- Heidemarie Ofner
- Marcus Hacker (ORCID: https://orcid.org/0000-0002-4222-4083)
- Holger Einspieler (ORCID: https://orcid.org/0009-0006-6617-0303)
- Gero Kramer (ORCID: https://orcid.org/0000-0003-1982-6817)
- Melanie R. Hassler (ORCID: https://orcid.org/0000-0002-9496-4411)
- Lukas Nics (ORCID: https://orcid.org/0000-0002-1034-876X)
- Shahrokh François Shariat (ORCID: https://orcid.org/0000-0002-6627-6179)
- Ilva Kristiana Langrate
Institutions
- University of Jordan (JO)
- Cornell University (US)
- Charles University (CZ)
- Comprehensive Cancer Center Vienna (AT)
- Karl Landsteiner Society (AT)
- Medical University of Vienna (AT)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1007/s00259-025-07448-z
- Citations
- 2
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Medizinische Universität Wien