Motor‐associated thalamic nuclei are reduced in juvenile myoclonic epilepsy
Motor-related ventral thalamic nuclei appear to be a core factor in JME pathogenesis. These motor-associated nuclei have known connections with premotor cortex, basal ganglion, and cerebellar pathways that are related to motor control. Their dysregulation may account for the myoclonus seen in JME and interictal motor effects. Further longitudinal investigation and comparison with other cohorts are needed. Targeted neuromodulation of JME may be possible.
Authors
- Nagesh Adluru (ORCID: https://orcid.org/0000-0001-8330-1770)
- Bruce P. Hermann (ORCID: https://orcid.org/0000-0003-0133-4427)
- Anusha Adluru (ORCID: https://orcid.org/0009-0008-6455-9299)
- Aaron F. Struck (ORCID: https://orcid.org/0000-0002-9103-1798)
- Dace N. Almane (ORCID: https://orcid.org/0000-0001-7889-5922)
- Camille Garcia‐Ramos
- Vivek Prabhakaran (ORCID: https://orcid.org/0000-0002-1974-3125)
- Veena A. Nair (ORCID: https://orcid.org/0000-0002-5666-3239)
- Jana E. Jones (ORCID: https://orcid.org/0000-0003-1723-0163)
- Santiago Philibert‐Rosas (ORCID: https://orcid.org/0000-0002-2521-334X)
Institutions
- University of Wisconsin–Madison (US)
- Washington University in St. Louis (US)
- William S. Middleton Memorial Veterans Hospital (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1111/epi.18571
- Citations
- 2
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- U.S. Department of Health and Human Services
- National Institute of Neurological Disorders and Stroke
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development