Altered along‐the‐perivascular space index in functional (psychogenic non‐epileptic) seizures: A diffusion tensor imaging study of glymphatic system function
The brain has a cleanup system called the glymphatic system, which removes waste to keep it functioning well. In this study, we examined whether this system works differently in people with functional seizures-seizures not caused by epilepsy. We compared brain scans from individuals with functional seizures and healthy controls. The results showed reduced activity in the glymphatic system, especially on the brain's left side, in those with functional seizures. This suggests that their brains may not clear waste as efficiently. Although this finding may point to brain differences in functional seizures, further research is needed to understand the connection.
Authors
- Fariba Khodagholi (ORCID: https://orcid.org/0000-0002-4911-4530)
- Mehrdad Roozbeh (ORCID: https://orcid.org/0000-0001-6043-2866)
- Mohammad Arbabi (ORCID: https://orcid.org/0000-0001-5368-2832)
- Ali A. Asadi‐Pooya (ORCID: https://orcid.org/0000-0002-2598-7601)
- Saba Amiri (ORCID: https://orcid.org/0000-0003-0909-240X)
- M.M. Mirbagheri (ORCID: https://orcid.org/0000-0003-1223-3197)
Institutions
- Northwestern University (US)
- Thomas Jefferson University (US)
- Royal Surrey County Hospital (GB)
- Northwestern University (PH)
- Northwestern Medicine (US)
- Shahid Beheshti University (IR)
- Shahid Beheshti University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1002/epi4.70089
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Brain Mapping Laboratory
- Shahid Beheshti University of Medical Sciences
- Neuroscience Research Center, Shahid Beheshti University of Medical Sciences