Macrophage migration inhibitory factor mediates joint capsule fibrosis via facilitating phospholipid metabolite PGE2 production in fibroblasts
Our results reveal a novel function of MIF-mediated fibroblast, which tunes pathological microenvironment by activating phospholipid metabolism to accelerate and exacerbate joint capsule inflammation and fibrosis. These suggest a new insights and potential therapeutic strategy for inflammation- and fibrosis-associated diseases.
Authors
- Renjie Xu (ORCID: https://orcid.org/0000-0002-6147-2453)
- Shilu Liu (ORCID: https://orcid.org/0000-0002-7138-7527)
- Zengguang Wang (ORCID: https://orcid.org/0000-0003-0569-3873)
- Xiaokun Yue
- Xiaoding Gu
- Yijia Wang (ORCID: https://orcid.org/0009-0005-3728-3555)
- Yuxin Zhang (ORCID: https://orcid.org/0000-0001-7224-2533)
- Yuntao Li (ORCID: https://orcid.org/0000-0001-8788-7537)
- Xin Jiao
- Han-Wen Chang
Institutions
- Jiangsu University (CN)
- Nanjing University of Chinese Medicine (CN)
- Shanghai Jiao Tong University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Shanghai Stomatological Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Second People's Hospital (CN)
- First People's Hospital of Kunshan (CN)
- Shanghai Center For Bioinformation Technology (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1007/s00018-025-05800-y
- Citations
- 9
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 7.18
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China