BACES score: a predictor of health-related quality of life and associated factors in patients with nontuberculous mycobacterial pulmonary disease

The evaluation of health-related quality of life (HRQOL) is gaining importance among patients with nontuberculous mycobacterial pulmonary disease (NTM-PD). We assessed whether the BACES score reflects HRQOL and associated factors in these patients. Data were collected from the nationwide NTM-KOREA prospective cohort of patients with NTM-PD who started antibiotic treatment and included symptoms, Quality of Life-Bronchiectasis (QOL-B) questionnaire, nutritional status using the Mini Nutritional Assessment-Short Form (MNA-SF) and Prognostic Nutritional Index (PNI), physical activity, body composition, spirometry, handgrip strength, and 6-min walking distance. Multivariate linear and logistic regressions were used for analysis. As the BACES score increased, so did the odds (adjusted odds ratio [95% confidence interval]) of cough (1.24 [1.04-1.48]), dyspnea (1.69 [1.28-2.27]), weight loss (1.78 [1.36-2.36]), and malnutrition, defined as MNA-SF score ≤ 7 (1.71 [1.21-2.45]), and PNI < 45 (2.14 [1.66-2.81]). The QOL-B respiratory symptom score (estimate: -2.259, P = 0.002) and 6-min walking distance (estimate: -18.015, P < 0.001) were negatively associated with the BACES score. Moreover, the odds of adipopenia (1.08 [1.03-1.13]), possible sarcopenia (1.80 [1.35-2.45]), and sarcopenia (2.09 [1.48-3.03]) increased in women. The BACES score can estimate HRQOL and associated conditions at antimicrobial treatment initiation in patients with NTM-PD.

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Journal
Scientific Reports
Published
2025-07-19
DOI
https://doi.org/10.1038/s41598-025-09971-3
Citations
2
Primary Topic
Mycobacterium research and diagnosis
Type
article
Field-Weighted Citation Impact
2.71

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article

BACES score: a predictor of health-related quality of life and associated factors in patients with nontuberculous mycobacterial pulmonary disease

Gyeong In Lee, Jeongha Mok, Doosoo Jeon, Kyung‐Wook Jo et al.
2 citations
Scientific Reports
Mycobacterium research and diagnosis
2.71
article

BACES score: a predictor of health-related quality of life and associated factors in patients with nontuberculous mycobacterial pulmonary disease

Gyeong In Lee, Jeongha Mok, Doosoo Jeon, Kyung‐Wook Jo, Byung Woo Jhun, Yong Soo Kwon, Youngmok Park, Hojoon Sohn, Nakwon Kwak, Jayoun Kim, Young Ae Kang, Jake Whang, Jae‐Joon Yim, Tae Sun Shim, Joong‐Yub Kim, Nanhee Park, Young Ran Kim, Hyung‐Jun Kim, Hyeontaek Hwang, Jae Ho Lee
article en
2 citations

Abstract

The evaluation of health-related quality of life (HRQOL) is gaining importance among patients with nontuberculous mycobacterial pulmonary disease (NTM-PD). We assessed whether the BACES score reflects HRQOL and associated factors in these patients. Data were collected from the nationwide NTM-KOREA prospective cohort of patients with NTM-PD who started antibiotic treatment and included symptoms, Quality of Life-Bronchiectasis (QOL-B) questionnaire, nutritional status using the Mini Nutritional Assessment-Short Form (MNA-SF) and Prognostic Nutritional Index (PNI), physical activity, body composition, spirometry, handgrip strength, and 6-min walking distance. Multivariate linear and logistic regressions were used for analysis. As the BACES score increased, so did the odds (adjusted odds ratio [95% confidence interval]) of cough (1.24 [1.04-1.48]), dyspnea (1.69 [1.28-2.27]), weight loss (1.78 [1.36-2.36]), and malnutrition, defined as MNA-SF score ≤ 7 (1.71 [1.21-2.45]), and PNI < 45 (2.14 [1.66-2.81]). The QOL-B respiratory symptom score (estimate: -2.259, P = 0.002) and 6-min walking distance (estimate: -18.015, P < 0.001) were negatively associated with the BACES score. Moreover, the odds of adipopenia (1.08 [1.03-1.13]), possible sarcopenia (1.80 [1.35-2.45]), and sarcopenia (2.09 [1.48-3.03]) increased in women. The BACES score can estimate HRQOL and associated conditions at antimicrobial treatment initiation in patients with NTM-PD.

Scientific ReportsVol. 15(1)
Ulsan College (KR), Seoul National University (KR), Yonsei University (KR), Severance Hospital (KR), Asan Medical Center (KR), Samsung Medical Center (KR), Seoul National University Hospital (KR), Seoul National University Bundang Hospital (KR), University of Ulsan (KR), Chonnam National University Hospital (KR), International Tuberculosis Research Center (KR), Pusan National University Hospital (KR), Pusan National University Yangsan Hospital (KR), Korea National Tuberculosis Association (KR), Pusan National University (KR), Sungkyunkwan University (KR)
Seoul National University, Seoul National University Hospital
Zero hunger
Openalex Percentile: Top 9%
Mycobacterium research and diagnosis
2.71
DOIOpen Access PDFOpenAlex
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