Early-onset difficult-to-treat rheumatoid arthritis: proposal of data-driven predictors and temporal threshold
In our cohort, the cut-off time for defining early developers of D2TRA-inefficacy was 44.5 months. The presence of ADS diagnosis, a higher CRP 6 months after the first b/tsDMARD, and being older at diagnosis were predictors of early development of D2TRA.
Authors
- José María Álvaro‐Gracia (ORCID: https://orcid.org/0000-0002-0343-3747)
- Marta Novella-Navarro (ORCID: https://orcid.org/0000-0002-2200-0859)
- P. Rodríguez-Merlos
- Chamaida Plasencia‐Rodríguez (ORCID: https://orcid.org/0000-0003-3503-9047)
- Virginia Ruíz-Esquide (ORCID: https://orcid.org/0000-0002-2657-6601)
- Raimón Sanmartí (ORCID: https://orcid.org/0000-0002-8864-3806)
- José Luis Cabrera-Alarcón (ORCID: https://orcid.org/0000-0003-2880-509X)
- Alejandro Balsa (ORCID: https://orcid.org/0000-0001-8070-7062)
- Chafik Chacur (ORCID: https://orcid.org/0000-0001-6781-0153)
- Eugenio De Miguel-Mendieta
Institutions
- Hospital Universitario La Paz (ES)
- Spanish National Centre for Cardiovascular Research (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Clínic de Barcelona (ES)
- Comunidad de Madrid (ES)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1186/s13075-025-03621-9
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundación Española de Reumatología