Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice
These findings demonstrate the overlapping and compensatory roles of Piezo1 and Piezo2 in OA pathogenesis. Dual inhibition of Piezo1 and Piezo2 may offer a novel, effective therapeutic strategy targeting both structural and symptomatic aspects of the disease.
Authors
- Kelsey H. Collins (ORCID: https://orcid.org/0000-0001-7348-7348)
- Lauryn Braxton
- Wolfgang Liedtke (ORCID: https://orcid.org/0000-0003-4166-5394)
- Yong Chen (ORCID: https://orcid.org/0000-0001-8818-4921)
- Kristin L. Lenz
- Farshid Guilak (ORCID: https://orcid.org/0000-0001-7380-0330)
- Sophie G. Paradi
- Erica V. Ely (ORCID: https://orcid.org/0000-0002-8813-2408)
- Seth Ack
- Abraham Behrmann
- Sarah Dunivan
Institutions
- Duke University (US)
- University of California, San Francisco (US)
- Saint Louis University (ES)
- Washington University in St. Louis (US)
- Shriners Hospitals for Children - St. Louis (US)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1186/s13075-025-03620-w
- Citations
- 5
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- Shriners Hospitals for Children
- National Institutes of Health
- Musculoskeletal Research Center, Washington University in St. Louis