Circ_HUWE1: a novel regulator of lipid accumulation, inflammation, and gut microbiota in atherosclerosis
Our study demonstrates for the first time that circ-HUWE1 exerts a protective effect against atherosclerosis by regulating lipid metabolism, macrophage infiltration and inflammatory responses through the miR-143-3p/IGFBP5 axis and reshaping the gut microbiota. These findings suggest circ_HUWE1 as a potential therapeutic target for atherosclerosis treatment.
Authors
- Yanru He (ORCID: https://orcid.org/0000-0002-6801-9088)
- Zhenjun Ji (ORCID: https://orcid.org/0000-0002-0299-8527)
- Zulong Sheng (ORCID: https://orcid.org/0000-0003-4292-2428)
- Yuyu Yao (ORCID: https://orcid.org/0000-0001-7841-288X)
- Yi Fan
- Genshan Ma (ORCID: https://orcid.org/0000-0003-4332-3013)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-1360-2452)
Institutions
- Zhongda Hospital Southeast University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1186/s13578-025-01440-8
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Southeast University
- Jiangsu Provincial Medical Youth Talent