CXCL12/CXCR4 modulates macrophage efferocytosis to induce glomerular crescent formation and fibrosis via ELMO1/DOCK180/RAC1 signaling in ANCA-associated glomerulonephritis
This study revealed that CXCL12/CXCR4 signaling axis plays a key regulatory role in the pathological process of AAGN. By establishing the specific molecular dialogue mechanism between endothelial cells and monocytes/macrophages, CXCL12 released by apoptotic endothelial cells can activate the CXCR4 on the surface of monocytes/macrophages, thereby promoting monocyte migration, enhancing macrophage-mediated efferocytosis and transforming into a pro-fibrotic phenotype. Targeted intervention with CXCL12/CXCR4 provides a promising approach for the treatment of AAGN.
Authors
- Yongqi Deng (ORCID: https://orcid.org/0000-0002-4550-7740)
- Shuo Wei (ORCID: https://orcid.org/0000-0002-2688-7952)
- Mo Wang (ORCID: https://orcid.org/0000-0003-1673-3631)
- Haohuan Li (ORCID: https://orcid.org/0000-0003-3215-5181)
- Hua-Ying Xiong
- Xin Cai (ORCID: https://orcid.org/0000-0001-9973-9494)
- Xiong Wang (ORCID: https://orcid.org/0000-0002-9778-7377)
- Wei Jiang (ORCID: https://orcid.org/0000-0002-4878-8381)
- Qiulin Li (ORCID: https://orcid.org/0000-0001-6011-1296)
- Yaxi Chen (ORCID: https://orcid.org/0000-0002-6242-7152)
- Qiu Li (ORCID: https://orcid.org/0000-0002-2481-7168)
- Liwen Tan (ORCID: https://orcid.org/0000-0002-7611-4034)
- Xiaomei Song
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1007/s00018-025-05750-5
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Key Technologies Research and Development Program