Human PXR Signaling Exacerbates Ethanol-induced Liver Injury in Females: Evidence From Mouse Models and Human Alcohol-associated Liver Disease Cohorts
These data indicate that hPXR-transgenic mice serve as a valuable in vivo model to elucidate mechanisms driving sexual dimorphism in ethanol-induced hepatotoxicity.
Authors
- Malvin Ofosu‐Boateng (ORCID: https://orcid.org/0000-0002-1407-1876)
- Suryakant Niture (ORCID: https://orcid.org/0000-0003-0613-9399)
- Sora Choi
- Daniel Okwudili Nnamani (ORCID: https://orcid.org/0000-0002-6788-3835)
- Suthat Liangpunsakul (ORCID: https://orcid.org/0000-0002-6504-8123)
- Nour Yadak
- Maxwell A. Gyamfi (ORCID: https://orcid.org/0009-0005-8403-9467)
- Lidya H Gebreyesus (ORCID: https://orcid.org/0000-0002-5540-637X)
- Frank J. Gonzalez (ORCID: https://orcid.org/0000-0002-7990-2140)
- Julia Yue Cui (ORCID: https://orcid.org/0000-0002-8564-1784)
- Elizabeth Twum
- Sarah Kim (ORCID: https://orcid.org/0000-0001-8079-5883)
- Deepak Kumar (ORCID: https://orcid.org/0000-0002-0418-5116)
Institutions
- North Carolina Central University (US)
- University of Tennessee Health Science Center (US)
- University of Washington (US)
- Richard L. Roudebush VA Medical Center (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101589
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism
- National Institute of Environmental Health Sciences
- National Institute on Minority Health and Health Disparities