CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA
CircABCA1 plays a crucial role in promoting ccRCC progression by regulating cholesterol metabolism and facilitating M2 macrophage polarization, representing a potential therapeutic target for ccRCC treatment.
Authors
- Hao Ning (ORCID: https://orcid.org/0000-0001-8132-5357)
- Linfei Li (ORCID: https://orcid.org/0000-0002-5217-3005)
- Jiao Li (ORCID: https://orcid.org/0000-0003-4200-5339)
- Ling Wei (ORCID: https://orcid.org/0000-0002-1825-8718)
- Junwu Ren (ORCID: https://orcid.org/0009-0006-1563-047X)
- Bin Xiao (ORCID: https://orcid.org/0000-0001-7159-4406)
- Ai Ran
- Wei Li (ORCID: https://orcid.org/0000-0003-2894-6263)
- Binbin Li (ORCID: https://orcid.org/0000-0001-7905-4340)
- Yan Jiang (ORCID: https://orcid.org/0000-0003-4769-8648)
- Yongquan Wang (ORCID: https://orcid.org/0000-0003-0414-6173)
- Z Li
- Cong Wang (ORCID: https://orcid.org/0009-0006-2448-3352)
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1186/s12943-025-02398-4
- Citations
- 16
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 12.76