Effects of Maackia amurensis seed lectin (MASL) on OSCC cell morphology, PDPN expression, growth, and motility in a phase 1 clinical trial
These results suggest that protocols using MASL and photoimmunotherapies that target PDPN can be developed to effectively treat OSCC lesions in oral cancer patients.
Authors
- Aki Furusawa (ORCID: https://orcid.org/0000-0002-1339-4219)
- Eugenio Capitle (ORCID: https://orcid.org/0000-0002-6170-0575)
- Ghayoour S. Mir (ORCID: https://orcid.org/0000-0003-3713-6772)
- Soly Baredes
- Ariel C. Yin
- Mika K. Kaneko (ORCID: https://orcid.org/0000-0002-4158-9208)
- Yukinari Kato (ORCID: https://orcid.org/0000-0001-5385-8201)
- Gary S. Goldberg
- Dylan F. Roden (ORCID: https://orcid.org/0000-0003-1476-4573)
- Evelyne Kalyoussef (ORCID: https://orcid.org/0000-0002-1016-0070)
- Mahnaz Fatahzadeh (ORCID: https://orcid.org/0000-0002-0720-4589)
- Eamonn J. Brace
- Rabie M. Shanti
- David Suster (ORCID: https://orcid.org/0000-0002-7986-4340)
- Alan J. Shienbaum
- Hisataka Kobayashi (ORCID: https://orcid.org/0000-0003-1019-4112)
- Cayla J. Holdcraft
- Tyler J Helmig
Institutions
- Rutgers, The State University of New Jersey (US)
- National Institutes of Health (US)
- Tohoku University (JP)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- Rutgers New Jersey Medical School (US)
- Rowan University (US)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1007/s00432-025-06265-z
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- New Jersey Health Foundation
- Osteopathic Heritage Foundation
- Japan Agency for Medical Research and Development
- National Institutes of Health