Modeling of pharmacokinetic/pharmacodynamic parameters in regular intermittent intravenous infusion and translational application of the models in personalized antibiotics dosing
The established AUC<sub>24</sub>/MIC and T<sub>>MIC</sub>% models displayed better performance relative to the documented models. Cooperative application of these models and the corresponding D<sub>d</sub> model can create a fully closed loop for evaluating the original scheme's effectiveness and developing the optimization regimen, and thus construct a basic framework for the creation of customized antibiotic regimens.
Authors
- Xiangqing Song (ORCID: https://orcid.org/0000-0001-5951-7280)
Institutions
- Central South University (CN)
- Hunan Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1186/s12967-025-06832-5
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province