Ten-year outcomes of IMRT with chemotherapy versus IMRT alone for stage II–IVa nasopharyngeal carcinoma: a retrospective study
In the era of IMRT, chemoradiotherapy was associated with manageable acute hematologic toxicity in patients with NPC. Distant metastasis, particularly in those with N3 disease, remained the predominant pattern of failure. Compared with IMRT alone, both CCRT (CCRT, NC + CCRT + AC, NC + CCRT) and non-CCRT (NC + IMRT + AC, IMRT + AC) demonstrated a potential survival benefit in newly diagnosed patients with locoregionally moderate or advanced NPC. These findings warrant further validation in prospective randomized clinical trials.
Authors
- Xiaolong Chang (ORCID: https://orcid.org/0000-0003-4700-6525)
- Furong Hao (ORCID: https://orcid.org/0000-0002-5402-0109)
- Li Yang (ORCID: https://orcid.org/0000-0001-6663-4629)
- Hui Yang (ORCID: https://orcid.org/0000-0002-6125-5985)
- Yunxiang Zhang (ORCID: https://orcid.org/0000-0003-3584-5962)
- Yanan Zhang (ORCID: https://orcid.org/0000-0001-7153-4358)
- Xiaoli Wang (ORCID: https://orcid.org/0000-0002-5498-7563)
- Jianwen Li (ORCID: https://orcid.org/0000-0001-5959-9861)
- Xiufeng Li (ORCID: https://orcid.org/0000-0002-0764-4613)
- Xue Meng (ORCID: https://orcid.org/0000-0001-6311-2649)
- Daqing Sun (ORCID: https://orcid.org/0000-0002-4311-3481)
Institutions
- Qingdao University (CN)
- Weifang Medical University (CN)
- Weifang People's Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-07-19
- DOI
- https://doi.org/10.1007/s12672-025-03230-7
- Citations
- 1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- Fudan University
- Chinese Academy of Medical Sciences