PD-1-Positive CD8+ T Cells and PD-1-Positive FoxP3+ Cells in Tumor Microenvironment Predict Response to Neoadjuvant Chemoimmunotherapy in Gastric Cancer Patients
Our findings identify PD-1<sup>+</sup> CD8<sup>+</sup> T cells and PD-1<sup>+</sup> FoxP3<sup>+</sup> Tregs as potential biomarkers of resistance to neoadjuvant chemoimmunotherapy in gastric cancer. Transcriptional programs centered on IL1B/CXCL5 and LGALS3/IDO1 define distinct immune phenotypes that may guide future combination strategies targeting both effector and suppressive arms of the tumor immune response.
Authors
- Sergey Vladimirovich Vtorushin (ORCID: https://orcid.org/0000-0002-1195-4008)
- Л. А. Таширева (ORCID: https://orcid.org/0000-0003-2061-8417)
- Irina Larionova (ORCID: https://orcid.org/0000-0001-5758-7330)
- Anna Yu. Kalinchuk (ORCID: https://orcid.org/0000-0003-2106-3513)
- Elena Kazakova (ORCID: https://orcid.org/0000-0001-6637-4417)
- А. В. Августинович
- Evgeniya S. Grigoryeva (ORCID: https://orcid.org/0000-0003-4737-8951)
- Dmitriy M. Loos
- Ivan A. Patskan (ORCID: https://orcid.org/0009-0008-4437-6583)
- E.A. Tsarenkova (ORCID: https://orcid.org/0009-0009-7955-1625)
- Pavel Iamschikov
Institutions
- Tomsk National Research Medical Center (RU)
Publication Details
- Journal
- Cancers
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3390/cancers17142407
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Cancer Research Institute
- Russian Science Foundation