Development of ZHPV16E7- granzyme B immunoaffitoxin: dual mechanisms targeting hpv16-positive cervical cancer through epithelial-mesenchymal transition inhibition and cell death
This study highlights the dual mechanism of ZHPV16E7-GrB, inhibiting EMT and inducing cell death (apoptosis and pyroptosis). These findings demonstrate its significant promise as a targeted therapeutic agent for HPV16-associated cervical cancer, addressing critical unmet needs in current treatment strategies.
Authors
- Shu Feng (ORCID: https://orcid.org/0000-0003-2346-5778)
- Xin Jing (ORCID: https://orcid.org/0000-0002-4671-3706)
- Xiaochun Tan
- Zhizhong Xie (ORCID: https://orcid.org/0000-0003-3365-0379)
- Lifang Zhang (ORCID: https://orcid.org/0000-0002-0548-1507)
- Yanheng Li
- Kairong Wan
- Jiani Yang
- Wenshu Li (ORCID: https://orcid.org/0000-0003-1017-471X)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Universitat de València (ES)
- Wenzhou Medical University (CN)
- Yancheng Third People's Hospital (CN)
- Yancheng Second People's Hospital (CN)
- First Hospital of Jiaxing (CN)
- Universitat Politècnica de València (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fimmu.2025.1616715
- Citations
- 2
- Primary Topic
- Toxin Mechanisms and Immunotoxins
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province