Cullin-3 and Regulatory Biomolecules Profiling in Vitiligo: Integrated Docking, Clinical, and In Silico Insights
Dysregulation of the CUL3/Keap1/NRF2 axis and elevated miRNA-146a levels correlate with vitiligo progression, suggesting a role for oxidative stress and immune imbalance. Vitexin's high-affinity docking to Keap1 positions it as a potential modulator of the NRF2 pathway, offering novel therapeutic avenues. This study highlights the translational potential of targeting the ubiquitin-proteasome and antioxidant pathways in the management of vitiligo.
Authors
- Noha M. Abd El‐Fadeal (ORCID: https://orcid.org/0000-0003-1852-4374)
- Ahmad J. Milebary
- Mohamed Azab (ORCID: https://orcid.org/0000-0002-2809-7428)
- Hidi A. A. Abdellatif (ORCID: https://orcid.org/0000-0002-5346-8956)
- Manal Said Fawzy (ORCID: https://orcid.org/0000-0003-1252-8403)
- Dhaifallah Alenizi (ORCID: https://orcid.org/0000-0001-8571-2231)
- Eman Hassan El-Sayed
- Rwan M. M. M. Halim
Institutions
- Suez Canal University (EG)
- Northern Border University (SA)
- Ibn Sina National College for Medical Studies (SA)
- King Fahd Armed Forces Hospital (SA)
- Alexandria University (EG)
Publication Details
- Journal
- Biomolecules
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3390/biom15071053
- Citations
- 1
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 1.15