Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
We model the fallopian tube preneoplastic landscape using a microfluidic platform to study EV-induced stress and show that cancer EVs promote immune signaling changes representing the earliest stages of ovarian cancer pathogenesis.
Authors
- Shailja Pathania (ORCID: https://orcid.org/0000-0001-8974-6420)
- Angela Russo (ORCID: https://orcid.org/0000-0002-7322-4190)
- Pamoda M. Galhenage
- Harsh B. Pathak (ORCID: https://orcid.org/0000-0003-4034-0520)
- Sagar Rayamajhi (ORCID: https://orcid.org/0000-0001-5420-7873)
- Brian P. Cain (ORCID: https://orcid.org/0000-0001-5946-9864)
- Mohammod Mahmudur Rahman (ORCID: https://orcid.org/0009-0000-4659-9299)
- Jared Sipes (ORCID: https://orcid.org/0009-0003-1065-3208)
- Mihaela E. Sardiu (ORCID: https://orcid.org/0000-0002-3987-7569)
- Rashna Madan
- Andrew K. Godwin (ORCID: https://orcid.org/0000-0002-3987-9580)
- Leonidas E. Bantis (ORCID: https://orcid.org/0000-0002-2364-2562)
- Shannon MacLaughlan David (ORCID: https://orcid.org/0000-0001-7374-5773)
- Rajni V. Puri (ORCID: https://orcid.org/0000-0002-0570-7350)
- Didi Zha (ORCID: https://orcid.org/0000-0003-1335-1435)
- Foyez Ahmmed (ORCID: https://orcid.org/0000-0002-6107-6637)
- Joanna E. Burdette (ORCID: https://orcid.org/0000-0002-7271-6847)
- Jonathan Coppeta (ORCID: https://orcid.org/0009-0005-2447-5320)
- Brett C. Isenberg (ORCID: https://orcid.org/0000-0001-7208-8804)
- Amrita Mitra (ORCID: https://orcid.org/0000-0002-1936-2189)
Institutions
- Boston University (US)
- Draper Laboratory (US)
- University of Kansas (US)
- Comilla University (BD)
- University of Massachusetts Boston (US)
- University of Illinois Chicago (US)
- The University of Kansas Cancer Center (US)
- Center for Personalized Cancer Treatment (NL)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0064
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institutes of Health
- Cancer Center, University of Kansas
- National Cancer Institute
- National Institute of General Medical Sciences