DNA/bovine serum albumin interaction studies and immunomodulatory effects of dinuclear platinum(II) complex with aromatic 1,5-naphthyridine bridging ligand
The DNA and bovine serum albumin binding evaluation of the dinuclear platinum(II) complex, [{PtCl(NH3)2}2(?-1,5-nphe)](ClO4)2 (1,5-nphe is the bridging 1,5-naphthyridine ligand) was investigated by UV?Vis and fluorescence emission spectroscopy. Influence of platinum(II) complex on immune response was also estimated. Peritoneal splenocytes isolated from BALB/c mice were treated with Concanavalin A (ConA) and platinum(II) complex. Concentrations of IFN-?, IL-1?, IL-17, TNF-? and IL-10 were measured and immunophenotyping was performed. Results showed notable immunomodulatory effects. Pt(II) complex has an inhibitory effect on the release of proinflammatory cytokines in ConA activated splenocytes and CD3+ T cells.
Authors
- Bojana Simović Marković (ORCID: https://orcid.org/0000-0001-8408-4624)
- Marina Jovanović (ORCID: https://orcid.org/0000-0002-7691-6133)
- Snežana Rajković (ORCID: https://orcid.org/0000-0002-7135-4063)
- Marija D. Živković (ORCID: https://orcid.org/0000-0002-1467-8002)
- Milena Jurišević (ORCID: https://orcid.org/0000-0002-0553-1156)
- Nevena Gajović (ORCID: https://orcid.org/0000-0003-0535-2964)
- Isidora Stanisavljević (ORCID: https://orcid.org/0009-0000-8308-8885)
- Jovana Z. Marinković (ORCID: https://orcid.org/0009-0007-6203-6657)
- Milica Obradović
- M. Jakovljeviç (ORCID: https://orcid.org/0009-0008-2762-1081)
- Katarina Mijacic
Institutions
- Military Medical Academy (RS)
- University of Kragujevac (RS)
Publication Details
- Journal
- Journal of the Serbian Chemical Society
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2298/jsc250411049m
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja