Nutrient restriction protects against valve interstitial cell calcification by upregulating ubiquitin mediated proteolysis
This study demonstrates that nutrient restriction effectively attenuates VIC calcification through the modulation of the ubiquitin-proteasome system. The protective role of UPS components, particularly Cul2 and Ube2H, suggests that targeting this pathway could represent a novel therapeutic approach for the management of CAVD. These findings also raise the possibility of employing dietary or metabolic interventions as non-invasive strategies to prevent or delay valve calcification.
Authors
- Kanchan Phadwal (ORCID: https://orcid.org/0000-0001-6745-9818)
- Xu Tan (ORCID: https://orcid.org/0000-0003-4861-4573)
- Dominic Kurian (ORCID: https://orcid.org/0000-0002-5924-665X)
- Qiyu Tang (ORCID: https://orcid.org/0000-0001-5483-5896)
- Vicky Elizabeth MacRae (ORCID: https://orcid.org/0000-0001-6306-7040)
- William P. Cawthorn (ORCID: https://orcid.org/0000-0001-7832-5057)
Institutions
- Roslin Institute (GB)
- The Queen's Medical Research Institute (GB)
- Anglia Ruskin University (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fcvm.2025.1586775
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council