Integrative UHPLC-HRMS and computational biology reveal ferroptosis and anoikis targeting by Wenpitongluo decoction in cardiorenal syndrome
This study systematically deciphers WPTLD's anti-CRS mechanisms via targeting ferroptosis- and anoikis-related genes through multi-pathway modulation. These findings not only clarify the pathological roles of ferroptosis and anoikis in CRS but also provide a computational framework for developing therapeutic strategies.
Authors
- Xinxin Mao
- Bingxuan Zhang
- Chunmei Chen (ORCID: https://orcid.org/0009-0000-0310-2713)
- Yumeng Li (ORCID: https://orcid.org/0000-0001-7220-6428)
- Qingqiao Song
- Shuqing Shi
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2025-07-21
- DOI
- https://doi.org/10.3389/fchem.2025.1617676
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- China Academy of Chinese Medical Sciences