Skeletal Muscle Fatigue in Rats Is More Consistently Related to Increased Inorganic Phosphate Concentration Than Acidosis
The inconsistent relationship between the decrease in twitch force and intramuscular hydrogen ion accumulation is not congruent with the primary mechanisms by which acidosis is thought to mediate muscle fatigue. In contrast, the discernible twitch force-inorganic phosphate breakpoint and the consistent relationship between the decrease in twitch force and intramuscular inorganic phosphate accumulation are congruent with the concept of a critical concentration beyond which inorganic phosphate mediates muscle fatigue.
Authors
- Matthew T. Lewis (ORCID: https://orcid.org/0000-0003-0580-6866)
- Ryan M. Broxterman (ORCID: https://orcid.org/0000-0002-7388-2214)
- Markus Amann (ORCID: https://orcid.org/0000-0002-4012-8880)
- Russell S. Richardson (ORCID: https://orcid.org/0000-0003-0233-5923)
- Robert W. Wiseman (ORCID: https://orcid.org/0000-0003-1832-7805)
- Fabio Giuseppe Laginestra (ORCID: https://orcid.org/0000-0003-4767-7249)
- Jesse C. Craig (ORCID: https://orcid.org/0000-0001-5959-4139)
Institutions
- University of Utah (US)
- Veterans Health Administration (US)
- Geriatric Research Education and Clinical Center (US)
- Michigan State University (US)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1111/apha.70083
- Citations
- 3
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 3.45
Funders
- Veterans Administration Medical Center
- Rehabilitation Research and Development Service
- Clinical Science Research and Development
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases