mRNA-LNP Vaccines Targeting SmpA-PLD and OmpK-Omp22 Induce Protective Immunity Against Acinetobacter baumannii
Our findings demonstrate mRNA-LNP vaccine technology as a versatile and promising platform for the development of innovative therapeutics against <i>A. baumannii</i>, with the potential to mitigate acute disease and promote bacterial decolonization. These findings pave the way for the development of urgently needed and effective antibacterial vaccines.
Authors
- Xingyun Wang
- Peng George Wang (ORCID: https://orcid.org/0000-0003-3335-6794)
- Xing Cheng (ORCID: https://orcid.org/0000-0003-2704-1323)
- Yunjiao He (ORCID: https://orcid.org/0000-0002-9480-9606)
- Jiahui Jin (ORCID: https://orcid.org/0000-0003-2546-5632)
- Cong Liu
- Yueling Zheng
- Xing‐Hua Gao (ORCID: https://orcid.org/0000-0001-8809-8564)
Institutions
- Southern University of Science and Technology (CN)
Publication Details
- Journal
- Vaccines
- Published
- 2025-07-19
- DOI
- https://doi.org/10.3390/vaccines13070764
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- National Key Research and Development Program of China