SIN1 facilitates glioma progression and is associated with the KRAS/ERK pathway
This study identifies SIN1 as a critical oncoprotein in glioma, upregulated in tumors and associated with aggressive features and poor survival. It drives tumor progression by enhancing proliferation/migration and suppressing apoptosis might via the KRAS4A/ERK pathway, while potentially modulating immune infiltration. These findings highlight SIN1's promise as a novel therapeutic target.
Authors
- Jing Ren (ORCID: https://orcid.org/0000-0003-1384-7369)
- Zhihan Yan
- Jing Wang (ORCID: https://orcid.org/0000-0003-0547-6780)
- Mengwei Li
- Dejun Yang
- Jinmin Sun
- Haowei Cao
- Haihan Zhang (ORCID: https://orcid.org/0000-0002-5902-7289)
- Yu Cheng (ORCID: https://orcid.org/0000-0002-0771-1580)
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1007/s11060-025-05166-y
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Xuzhou Medical University