Exploratory Metabolomic and Lipidomic Profiling in a Manganese-Exposed Parkinsonism-Affected Population in Northern Italy
Mn exposure and Parkinsonism are associated with distinct metabolic and lipidomic perturbations. These findings support the utility of omics in identifying environmentally linked Parkinsonism biomarkers and mechanisms.
Authors
- Haiwei Gu (ORCID: https://orcid.org/0000-0002-7598-5022)
- Hari Krishnan Krishnamurthy (ORCID: https://orcid.org/0000-0002-7832-8423)
- Yan Jin (ORCID: https://orcid.org/0000-0001-7075-0366)
- Patrizia Crippa
- Somaiyeh Azmoun (ORCID: https://orcid.org/0000-0003-4951-614X)
- Elena Colicino (ORCID: https://orcid.org/0000-0002-1875-8448)
- Fulvio Pepe (ORCID: https://orcid.org/0009-0002-6437-1110)
- Roberto G. Lucchini (ORCID: https://orcid.org/0000-0002-9723-0237)
- Alessandro Padovani (ORCID: https://orcid.org/0000-0002-0119-3639)
- Donatella Placidi (ORCID: https://orcid.org/0000-0003-1606-5397)
- Xuexia Wang (ORCID: https://orcid.org/0000-0002-0613-2608)
- Andrea Pilotto
- Daniel Shoieb
- Freeman Lewis
- Jinhua Chi
- Marinella Tula
Institutions
- University of Modena and Reggio Emilia (IT)
- Florida International University (US)
- Villa Pineta Hospital (IT)
- Fondazione Poliambulanza Istituto Ospedaliero (IT)
- Vibrant Data (United States) (US)
- Domus Medica (BE)
- University of Brescia (IT)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Metabolites
- Published
- 2025-07-20
- DOI
- https://doi.org/10.3390/metabo15070487
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro
- National Institute of Environmental Health Sciences