0351 Decreased incidence of acanthosis nigricans in patients with obesity taking GLP-1 agonists

This retrospective cohort study evaluates whether patients with obesity taking GLP-1 agonists have decreased incidence of acanthosis nigricans compared to matched controls taking metformin, a common systemic treatment for AN. Insulin resistance and subsequent hyperinsulinemia have been shown to be linked to the epithelial changes characteristic of obesity-associated AN. TriNetX data between 2005 and 2025 was used to analyze the risk of developing AN after an obesity diagnosis and starting an insulin sensitizer, either a GLP-1 agonist or metformin.