0617 Reconstituting systemic immunity with hematopoietic stem cell transplantation remodels the human skin microbiome in DOCK8 deficiency
The human skin microbiome (bacteria, fungi, viruses) exists in equilibrium with skin immunity. Studies have elucidated microbial influences on immunity, yet understanding how altered immunity perturbs the equilibrium remains limited. We investigated the dual impact of immune deficiency and hematopoietic stem cell transplantation (HSCT) on skin microbiomes in DOCK8 deficiency (n=24), a rare inborn error of immunity with impaired innate and adaptive immunity, eczema, chronic systemic/skin infections, and increased cancer risk.
Authors
- Clay Deming (ORCID: https://orcid.org/0000-0002-7745-1518)
- Stefania Pittaluga (ORCID: https://orcid.org/0000-0001-7688-1439)
- Zeyang Shen (ORCID: https://orcid.org/0000-0003-3870-1390)
- Chen Zhao (ORCID: https://orcid.org/0000-0003-1361-8419)
- Helen C. Su (ORCID: https://orcid.org/0000-0002-5582-9110)
- H.H. Kong
- Nirali N. Shah (ORCID: https://orcid.org/0000-0002-8474-9080)
- Isaac Brownell (ORCID: https://orcid.org/0000-0002-0090-9914)
- J. Han
- Dennis D. Hickstein (ORCID: https://orcid.org/0000-0002-1697-7209)
- Steve Holland
- K. Nagao
- Matilda Bingham
- Sean Conlan (ORCID: https://orcid.org/0000-0001-6848-3465)
- Alexandra F. Freeman (ORCID: https://orcid.org/0000-0001-7005-8345)
- Clive Holmes (ORCID: https://orcid.org/0000-0003-1999-6912)
- S. Balakrishna Pai (ORCID: https://orcid.org/0000-0003-2662-253X)
- Cristina González (ORCID: https://orcid.org/0000-0002-6924-990X)
- Charles Harkins
- Leslie Castelo‐Soccio (ORCID: https://orcid.org/0000-0003-3289-446X)
- Stefania Dell’Orso (ORCID: https://orcid.org/0000-0002-1634-5631)
- Ying Che (ORCID: https://orcid.org/0000-0002-0044-4168)
- Julia A. Segre (ORCID: https://orcid.org/0000-0001-6860-348X)
- Peimin Hou
- Aref Amirkhani
- Hanna Englander
Publication Details
- Journal
- Journal of Investigative Dermatology
- Published
- 2025-07-21
- DOI
- https://doi.org/10.1016/j.jid.2025.06.625
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00