LB1069 Associations of exposure to acrylamide and glycidamide with psoriasis among adults: Findings from a population-based study

Acrylamide (AA), a hazardous chemical prevalent in the environment and human diet, and its metabolite glycidamide (GA) are suspected contributors to psoriasis. However, the relationship between AA, GA exposure and psoriasis incidence remains unclear. Using data from the National Health and Nutrition Examination Survey (NHANES) cycles 2003-2004, 2005-2006, and 2013-2014, we conducted a cross-sectional study involving 6,999 participants. While no overall association was observed between AA-hemoglobin adduct (HbAA), HbGA levels, and psoriasis risk, subgroup analyses revealed positive relationships among individuals aged 20-40 years and those with serum cotinine levels between 0.011 and 10 ng/mL.